NMR Data Evaluation: Review of Covariance Applications

Covariance NMR has attracted considerable interest in recent years and new applications of this technique aimed at paving the way forward to structure elucidation are appearing frequently in the scientific literature. For example, Zhang and coworkers used Covariance TOCSY NMR to improve the resolution of 2D spectra and simplify the task of mixtures analysis.1 The objectives of this technique are manifold, ranging from the resolution enhancement of homonuclear 2D spectra to the generation of new spectra that would require longer acquisition times by “combining” two spectra with a lower time “cost”.